99% Purity Cladribine Raw Materials Powder CAS 4291-63-8 Cladribine

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: 99%
• Model NO.: HRK-Cladribine
• Product Name: Cladribine
• Certificate: GMP ISO USP Bp
• Assay: 99% Min Cladribine
• Test: HPLC
• Mf: C10h12cln5o3
• MW: 285.69
• Active Ingredient: Cladribine Raw Materials
• Sample: Cladribine Avaliable
• Brand Name: Henrikang
• Application: Cladribine
• Type of Product: Auxiliaries and Other Medicinal Chemicals
• Storage: Cool Dry Place
• Shelf Life: 2 Years Proper Storage
• Grade Standard: Medicine Grade
• Model Number: Hrk-Cladribine
• Transport Package: 1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr
• Specification: 99% min Cladribine
• Trademark: Henrikang
• Origin: Shaanxi China
• Production Capacity: 500000kg/Year

Product Description

99% Purity Cladribine Raw Materials Powder CAS 4291-63-8 Cladribine

Product name	Safe Shipping Purity Cladribine Powder CAS 4291-63-8 Cladribine Raw Materials Antineoplastic Cladribine
Appearance	WHITE Powder
MF	C10H12ClN5O3
MW	285.69
Assay	99%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

What is Cladribine ? It is mainly effective for hair cell leukemia, and it is also effective for other lymphomas and leukemia. Cladribine exerts remarkable activity against hair-cell leukemia (HCL), a chronic B-lymphocytic hyperplasia disease, prolongating complete remission. Cladribine induces the accumulation of DNA strand breaks and subsequently activates the tumor suppressor gene p53 in lymphocytes. Cladribine may regulate STAT3 activity in MM cells. Cladribine inhibited proliferation/survival of U266, RPMI8226 and MM1.S cells in a dose-dependent manner. U266 had the lowest sensitivity to cladribine and the highest sensitivity to MM1.S.

Function of Cladribine

Treatment with Cladribine gradually increased the proportion of G1 phase cells in the cell cycle
and decreased S phase cells. Treatment with Cladribine for 24 hours appeared to increase the
proportion of G2-M phase in U266 cells. A dose-dependent increase in apoptosis induced by
cladribine was observed in both RPMI8226 and MM1.S cells. Time-dependent treatment with
0.2μMcladribine significantly induced caspase-3, -8, and -9 activation and PARP cleavage in
MM1.S.

Safe Shipping Purity Cladribine Powder CAS 4291-63-8 Cladribine Raw Materials Antineoplastic Cladribine
Purity Cladribine Powder;Cladribine Raw Materials    ;Antineoplastic Cladribine