| CAS No.: | 14698-29-4 |
|---|---|
| Formula: | C13h11no5 |
| EINECS: | 238-750-8 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Refined |
| Samples: |
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| Customization: |
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| Product name | High Purity Organic Oxolinic Acid Powder CAS 14698-29-4 Oxolinic Acid |
| Appearance | White Powder |
| CAS | 14698-29-4 |
| MF | C13H11NO5 |
| MW | 261.23 |
| Assay | 99%min Berberine sulfate |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
|
What is Oxolinic acid ?Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12-20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice. |
Function of Oxolinic Acid
Oxolinic Acid is a kind of ketone fungicide , used in rice seed treatment, is the first fungicide with outstanding
effect on rice bacterial disease. The occurrence of bacterial bacterial disease can be prevented by chemical
treatment before sowing. The mechanism of action is that it has a wide range of antibacterial activity against
gram negative bacteria, but has a weak activity against gram positive bacteria and no activity against fungi.
By inhibiting the synthesis of DNA, it prevents bacteria from dividing and multiplying. In the bacterial body, the
reverse hypercrimp enzyme is introduced into the hypercrimp structure of DNA. This agent can bind to the
subgroup A of this enzyme, thereby inhibiting its function and making DNA unable to replicate, which will soon
cause death. The seeds were immersed in 1000g/mL for 24h
Application of Oxolinic Acid
This product belongs to the first generation of quinolones, and its mechanism of action is to inhibit the
synthesis of bacterial deoxynucleotides. It has strong antibacterial effect on gram-negative bacteria, but
no antibacterial effect on fungi and mycobacterium tuberculosis. The MIC50 was 0.02 ~ 0.09 g/ml. Carps
were given oral infusion of 5mg/kg, 10mg/kg, 20mg/kg and 40mg/kg for a single time. After 15-24h, the
blood concentration peaked, and the blood concentration maintained above 0.2 g/ml for 66h. The toxicity
of this product is very small, acute toxicity test for carp oral LD50 is more than 4000mg/kg.
High Purity Oxolinic Acid Powder CAS 14698-29-4 Material Purity Oxolinic Acid
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