Natural Food Grade Daidzein Organic Soybean Extract Daidzein 98% for Antioxidant
| Product Name |
Organic Soybean Extract Daidzein Powder CAS 486-66-8 Daidzein Used for Antiarrhythmic |
| Appearance |
White powder |
| Part |
Leaf |
| Application |
Antiarrhythmic |
| Organic |
EU & NOP |
| Purity |
80% |
| Storage |
Keep in a cool, dry, dark location |
| Shelf Life |
24 months when properly stored |
What is Daidzein ?
As one of the main effective components of pueraria and soybean, daidzein (4 ',7 1, 2 hydroxyl isoflavone, D for short) has obvious effects on anti-arrhythmia, anti-hypoxia and ischemia, antispasticity, estrogen, promoting the formation of bone cells and inhibiting the growth of cancer cells. Tablets or capsules made from D are mainly used to treat coronary heart disease, cerebral thrombosis, cerebral infarction and sequelae of cerebral hemorrhage. It can also be used for neck pain, headache, dizziness and early sudden deafness caused by hypertension. However, due to the limitation of D molecular structure, both water solubility and fat solubility are poor, leading to some drawbacks in clinical application, such as low bioavailability, large dosage, and slow absorption of tablets or capsules in the body, which can only be effective 7-14d. In order to improve the solubility of D and solve the problems in clinical application, about 50 D derivatives have been reported at home and abroad. Taking D as the lead compound, it is an important task to modify its chemical structure and search for derivatives with strong bioactivity and high availability
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Function of Daidzein
Daidzein (3.0,5.0mg·kg-1) can prevent ventricular fibrillation induced by chloroform in mice, and daidzein (0.8,1.0mg·kg-1)
can treat arrhythmia induced by aconitine in rats. Daidzein (0.2,0.3mg·kg-1) can also inhibit the arrhythmia induced by adrenalin
in rabbits, and daidzein (0.03%,0.05%) can significantly reduce the amplitude of sciatic nerve action potential in toad in vitro.
Daidzein (0.8,1.0mg·kg-1) can prevent ventricular fibrillation induced by calcium chloride and significantly reduce the mortality
of rats. The above effects were dose-dependent.
Application of Daidzein
Daidzein has obvious antiarrhythmic effect. Aconitine can promote the opening of fast sodium channels and accelerate Na+
flow, resulting in multi-source ectopic rhythm. Daidzein can effectively counteract this, suggesting that daidzein may have an
obvious inhibitory effect on the Na+ flow of myocardial membrane. Daidzein also has a procaine-like local anesthetic effect,
with a similar ability to penetrate the sciatic nerve as procaine-like. The action potential amplitude of isolated sciatic nerve of
toad was mainly caused by Na+ influx, which was decreased by daidzein, which further indicated that daidzein had an inhibitory
effect on Na+ influx. Therefore, the antiarrhythmic effect of daidzein may be related to the inhibition of Na+ or Ca2+ influx and
the anti-β-adrenergic receptor.
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