Hot Sale Terbinafine Hydrochloride Powder Factory Price Healthcare Supplement
Terbinafine HCl
| Product Name |
Henrikang Factory Supply Terbinafine Hydrochloride Powder CAS 78628-80-5 Terbinafine HCL |
| CAS |
78628-80-5 |
| Appearance |
white powder |
| Molecular formula |
C21H26ClN |
| Molecular Weight |
327.9 |
| Assay |
98% |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
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What is Terbinafine HCl?
Terbinafine HCL a synthetic antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine·HCl a member of the class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed
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Function of Terbinafine hydrochloride
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in and , soluble in ethanol,
and slightly soluble in water. Like other , terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase
, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion
ofsqualene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability
, causing fungal cell lysis.
Application of Terbinafine hydrochloride
1. Terbinafine HCL is mainly effective on the dermatophyte group of fungi.
2. As a 1% cream or powder, Terbinafine HCL is used topically for superficial skin infections such as jock itch
(tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works
in about half the time required by other antifungals.
3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically
by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to
which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause
hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to oral
administration have been studied.
4.Terbinafine HCLmay induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus
erythematosus should first discuss possible risks with their doctor before initiation of therapy.
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Packaging & Logistics
Package:
1kg per Foil Bag, 10 Bags per carton. 25 kg per Drum. Or Customized Package.
2. Shipping Advise:
1. By Express
------Suitable for under 50kg, Fast:3-4 days. High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:4-5 days, High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 15-45 days, Low cost. Port to Port, professional broker needed.
why choose us ?
Henrikang Factory Supply Terbinafine Hydrochloride Powder CAS 78628-80-5 Terbinafine HCL
Terbinafine Hydrochloride;Terbinafine HCL;CAS 78628-80-5 Terbinafine HCL
Terbinafine Hydrochloride
CAS:78628-80-5
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