Factory Price Terbinafine Hydrochloride Powder CAS 78628-80-5 Terbinafine HCl for Anti Infection

• CAS No.: 78628-80-5
• Formula: C21h26cln
• EINECS: 616-640-4
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: HRK-Terbinafine Hydrochloride
• Colour: White
• Product Name: Terbinafine Hydrochloride Powder
• Test: HPLC
• Mf: C21h26cin
• CAS: 78628-80-5
• MW: 327.89
• Active Ingredient: Terbinafine Hydrochloride
• Sample: Terbinafine Hydrochloride Avaliable
• Certificate: GMP ISO USP Bp
• Assay: 90% Min
• Grade Standard: Medicine Grade
• Application: API Raw Materials
• Type of Product: Auxiliaries and Other Medicinal Chemicals
• Storage: Cool Dry Place
• Shelf Life: 2 Years Proper Storage
• Factory: GMP Standard
• Transport Package: 1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr
• Specification: 99% min Terbinafine Hydrochloride
• Trademark: Henrikang
• Origin: Shaanxi China
• Production Capacity: 500000kg/Year

Product Description

                   

Product Name	Good Quality Terbinafine Hydrochloride CAS 78628-80-5 Lamosil Terbinafine for Antifungal
CAS	78628-80-5
Appearance	White crystalline powder
Molecular formula	C21H26CIN
Molecular Weight	327.89
Assay	98%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

 

What is Terbinafine hydrochloride?   Terbinafine hydrochloride 78628-80-5 a synthetic antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine·HCl 78628-80-5 a member of the class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition.  Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Additionally, Terbinafine 78628-80-5 has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed.

Function of Terbinafine hydrochloride

Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in and , soluble in ethanol,
and slightly soluble in water. Like other , terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase,
an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion
ofsqualene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability,
causing fungal cell lysis.

Application of Terbinafine hydrochloride


1. Terbinafine hydrochloride is mainly effective on the dermatophyte group of fungi.

2. As a 1% cream or powder, Terbinafine hydrochloride is used topically for superficial skin infections such as
jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream
works in about half the time required by other antifungals.

3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by
a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which
topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity,
so patients are warned of this and may be monitored with liver function tests. Alternatives to oral administration have
been studied.

4.Terbinafine HCLmay induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus
erythematosus should first discuss possible risks with their doctor before initiation of therapy.

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Packaging & Logistics

Package:

1kg per Foil Bag, 10 Bags per carton. 25 kg per Drum. Or Customized Package.
 

2. Shipping Advise: 

1. By Express

------Suitable for under 50kg, Fast:3-4 days. High cost; Door to door service. Easy to pick up the goods.

2. By Air 

------Suitable for more than 50 kg, Fast:4-5 days, High cost, airport to airport. professional broker needed.

3. By sea

------Suitable for more than 500kg. Slow: 15-45 days, Low cost. Port to Port, professional broker needed.

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