China Top Quality Pharmaceutical Ingredient Ademetionine disulfate tosylate (SAMe) powder
|Product Name||Ademetionine disulfate tosylate (SAMe)|
|Appearance||White fine powder|
|Assay||99%min, 98.0% --101.0%|
|Shelf Life||24 months when properly stored|
|Storage||Keep in a cool, dry, dark location|
What is Ademetionine disulfate tosylate (SAMe) ?
S-Adenosyl-l-methionine Disulfate Tosylate (SAMe for short) is a common cosubstrate involved in methyl group transfers.
SAM was first discovered in Italy by G. L. Cantoni in 1952, can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis,
SAM is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday SAM is commonly used in pharmaceuticals, health care food industry both at domestic and international market.
Function of Ademetionine disulfate tosylate (SAMe)
1.S-Adenosyl-L-methionine is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury;
2.S-Adenosyl-L-methionine has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.
3.S-Adenosyl-L-methionine has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.
Application of Ademetionine disulfate tosylate (SAMe)
1. S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 18.104.22.168). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.
2 .The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.
3 .In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.
4 .Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 22.214.171.124) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.
5 .SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.
6 .In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.
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Packaging & Logistics
1kg per Foil Bag, 10 Bags per carton. 25 kg per Drum. Or Customized Package.
2. Shipping Advise:
1. By Express
------Suitable for under 50kg, Fast:3-4 days. High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:4-5 days, High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 15-45 days, Low cost. Port to Port, professional broker needed.
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