Pharmaceutical Intermediate Tideglusib Raw Powder CAS 865854-05-3 Tideglusib
| Product name |
Pharmaceutical Intermediate Tideglusib Raw Powder CAS 865854-05-3 Tideglusib |
| Appearance |
White crystalline particle |
| MF |
C19H14N2O2S |
| Assay |
98% |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
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What is Tideglusib ?
Tideglusib irreversibly inhibits GSK-3 in human neuroblastoma cells and mouse primary neurons, thereby reducing tau phosphorylation levels and preventing apoptosis. Tideglusib(2.5μM) inhibits glutamate-induced glial activation, as evidenced by decreased expression levels of TNF-α and COX-2 in primary astrocytes or microglia in rats. Tideglusib(2.5μM) also has an effective protective effect on cortical neurons against glutamate-induced neuroexcitatory toxicity, as evidenced by a significant decrease in Annexin-V positive cells in rat primary astrocytes or microglia
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Application of Tideglusib
Tideglusib (50 mg/kg) injected into the hippocampus of adult male Wistar rats significantly reduced the rhodosine-induced
inflammatory response and protected the damaged area of the hippocampus. In APP/tau dual transgenic mice, Tideglusib
(200 mg/kg orally) reduced tau phosphorylation levels, reduced amyloid deposition and patch-related astrocyte proliferation,
protected neurons in the entorhinal cortex and hippocampal CA1 region from death, and prevented memory loss
Function of Tideglusib
Tideglusib (NP031112, NP-12) is an irreversible, non-ATP-competitive inhibitor of GSK-3β with an IC50 of 60 nM in cell-free
trials and does not inhibit Cys kinase at the active site, which is also derived from CYS-199. Phase 2.
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Packaging & Logistics
Package:
1kg per Foil Bag, 10 Bags per carton. 25 kg per Drum. Or Customized Package.
2. Shipping Advise:
1. By Express
------Suitable for under 50kg, Fast:3-4 days. High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:4-5 days, High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 15-45 days, Low cost. Port to Port, professional broker needed.
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