CAS No.: | 1140909-48-3 |
---|---|
Formula: | C32h30fn3o10 |
EINECS: | C32h30fn3o10 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Technical |
Samples: |
---|
Customization: |
---|
Suppliers with verified business licenses
Product Name
|
Cabozantinib Malate |
Appearance
|
white powder |
Assay
|
99%min, 98.0% --101.0% |
Test
|
HPLC
|
Certificate
|
ISO 9001
|
CAS
|
1140909-48-3 |
MF | C32H30FN3O10 |
Storage Temperature |
Cool Dry Place
|
Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
Cabozantinib Malate is an anti-cancer drug.Cabozantinib Malate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration(0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion.
Suppliers with verified business licenses