Pharmaceutical Intermediate Lovastatin Powder CAS 75330-75-5 Raw Materials Purity
Lovastatin
| Product Name |
Pharmaceutical Intermediate Lovastatin Powder CAS 75330-75-5 Raw Materials Purity Lovastatin |
| CAS |
75330-75-5 |
| Appearance |
White Powder |
| Molecular formula |
C9H11NO4 |
| Molecular Weight |
C24H36O5 |
| Assay |
98% |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
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What is Lovastatin ?
Lovastatin is a hexahydronaphthyl ester isolated from the culture medium of Aspergillus terreus. It is an inactive lactone that can only become active after oral administration and hydrolysis. HMG-CoA reductase is the rate-limiting enzyme for de novo cholesterol synthesis in vivo. Inhibition of HMG-CoA reductase can block the conversion of HMG-coa to methylvalerate, significantly reduce cholesterol synthesis, enhance the expression of LDL receptor in liver, and enhance the clearance of LDL-C in plasma.
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Natural statin compound structure is very similar, they have the same (hydroxylhexahydronaphthalene) poly
ketone ketone hydroxyl hydrogen six ring part, different side chain connected to the C8 (R1) and C6 (R2). h
e R1 of lovastatin was methyl butyryl side chain, and R2 was 6-α-methyl. Mevastatin has no 6-position meth
yl group. Natural statins exist in the form of lactone, which requires enzymatic hydrolysis to acid form in vivo
to be active. Although different from natural statins in structure, fully synthetic statins still have a ring-opening
lactone moiety, which has the common structure of all statins that competitively inhibits HMG-CoA reductase.
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