| Powder: | Yes |
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| Customized: | Customized |
| Certification: | GMP, USP, BP |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Purity: | >99% |
| Samples: |
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| Customization: |
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| Product Name | API Tacrolimus 99% Raw Powder with Bottom Price Tacrolimus Pharmaceutical Chemicals GMP |
| CAS | 104987-11-3 |
| Appearance | White fine powder |
| MF | C44H69NO12 |
| MW | N/A |
| Assay | 99% |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
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What is Tacrolimus?
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug.It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
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Function and Application of Tacrolimus 1. Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. 2. Tacrolimus is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. 3. Tacrolimus can be combined with steroids, azathioprine (Imuran Azasan) or mycophenolate mofetil (CellCept |
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